State Road 358, located east of Edwardsport, is expected to remain closed through the week, according to the Knox County Emergency Management Agency.
The river is expected to crest around 22 feet early Tuesday morning, with three feet of water flowing across the roadway.
Additionally, State Road 257 in Daviess County is also closed due to flooding.
Authorities remind drivers to avoid driving through any flooded roads for their safety.
